Govind Pai – Postdoc

Research interests
We are interested in how defective DNA interstrand crosslink (ICL) repair in individuals with the heritable Fanconi Anaemia (FA) gives rise to tumours of the head and neck. Besides understanding the fundamental biology of these tumours, our efforts are to uncover new, targetable vulnerabilities of therapeutic value, using genome-wide, synthetic lethality screens.
We are also interested in how the mTORC1 cellular growth signalling pathway, when over-activated may cause “harmful” DNA replication stress in the context of multiple tumour types.