At the Amsterdam UMC Department of Human Genetics, the Oncogenetics section investigates genes and genetic networks that contribute to hereditary and sporadic cancers.
Our research is directed at functionally characterizing genes involved in hereditary cancer predispositions, and exploring their roles in general cancer biological mechanisms. Research findings are translated into future clinical applications whenever possible. We collect liquid biopsies of cancer gene carriers to explore novel ways of early detection.
We use multiple molecular -omics approaches to investigate patient-derived and CRISPR-engineered cancer cell models. By functional CRISPR genomics and bio-informatics we aim to reveal synthetic lethalities and druggable pathways that allow the identification of novel biomarkers and therapeutic strategies,
Our lab co-hosts the Amsterdam UMC CRISPR Expertise Center and invests in novel CRISPR applications directed at functional genomics, RNA and DNA detection and experimental gene therapy.
Contact
Rob Wolthuis
Lab Head / Principal Investigator
E: r.wolthuis@amsterdamumc.nl
Address
Cancer Center Amsterdam
CCA2.21
De Boelelaan 1118
1081 HV Amsterdam
the Netherlands