As part of the Human Genetics department of Amsterdam UMC (location VUmc), the Oncogenetics section investigates genes and pathways that underlie hereditary and sporadic cancers. By using patient-derived and CRISPR-engineered human cell models and a range of molecular and -omics approaches, we generate genetic networks and perform functional studies to reveal synthetic lethalities and druggable pathways.
Areas of interest include:
– Hereditary genetic cancer predispositions and related syndromes
– Mechanisms of DNA replication and repair and DNA organization by cohesin complexes
– Aberrant expression of normally meiosis-specific genes in cancer.
Moreover, we collect liquid biopsies of cancer gene carriers and patients for novel cancer diagnostics and invest in CRISPR technology for diagnostic and therapeutic purposes. Our lab also hosts the Amsterdam UMC CRISPR Expertise Center.
For more information about the different research lines, vacancies and possibilities for research internships, visit the specific subpages or contact one of the principal investigators.
Contact
Rob Wolthuis
Lab Head / Principal Investigator
E: r.wolthuis@amsterdamumc.nl
Address
Cancer Center Amsterdam
CCA2.21
De Boelelaan 1118
1081 HV Amsterdam
the Netherlands