Job de Lange – Principal investigator

Research interests
The research of the ‘cohesion team’ is centered on cohesin, a circular protein complex involved in multiple aspects of chromosome organisation. Our focus includes a variety of genetic syndromes related to impaired cohesin functioning, termed cohesinopathies, as well as cancer. Among various other aproaches, we generate genetic interaction networks of cohesion regulators in the presence of clinically relevant drugs, to gain insight into their specific functions and identify specific vulnerabilities of cancer cells with defective sister chromatid cohesion.


De Lange group